O-GlcNAcylation and Its Role in Cancer-Associated Inflammation

Apr 1, 2022·
Muzi Ouyang (Mia)
Muzi Ouyang (Mia)
,
Changmeng Yu
,
Xiaolian Deng
,
Yingyi Zhang
,
Xudong Zhang
,
Fangfang Duan
· 0 min read
DOI
Abstract
Cancer cells, as well as surrounding stromal and inflammatory cells, form an inflammatory tumor microenvironment (TME) to promote all stages of carcinogenesis. As an emerging post- translational modification (PTM) of serine and threonine residues of proteins, O-linked-N- Acetylglucosaminylation (O-GlcNAcylation) regulates diverse cancer-relevant processes, such as signal transduction, transcription, cell division, metabolism and cytoskeletal regulation. Recent studies suggest that O-GlcNAcylation regulates the development, maturation and functions of immune cells. However, the role of protein O-GlcNAcylation in cancer-associated inflammation has been less explored. This review summarizes the current understanding of the influence of protein O-GlcNAcylation on cancer-associated inflammation and the mechanisms whereby O-GlcNAc-mediated inflammation regulates tumor progression. This will provide a theoretical basis for further development of anti-cancer therapies.
Type
Publication
Frontiers in Immunology, 13, 861559
Status
Peer-reviewed Open access
publications
O-GlcNAcylation Tumour Immunology Inflammation
Muzi Ouyang (Mia)
Authors
Muzi Ouyang (Mia)
PhD Candidate

I am Muzi Ouyang (欧阳木子) — I go by Mia. I am a PhD candidate in Chemistry at Tsinghua University, advised by Prof. ADVISOR NAME. My research is on YOUR TOPIC — ONE SENTENCE ON WHAT YOU FOUND OR BUILT.

My background spans animal science, basic medicine and chemistry, so I work comfortably at the interface between them. (Rewrite or delete this line — but a deliberate framing of an interdisciplinary path reads as a strength, whereas leaving it unexplained invites the question.)

I expect to defend in June 2027 and am seeking postdoctoral positions starting in late 2027. If my work overlaps with your group’s, I’d be glad to hear from you — my CV is linked above. Write to me at mumumia.1009@gmail.com, or oymzmia@163.com if you are corresponding from within China.